GeneID: 199
Names
Common Name: | GSTT1 | Type: | Gene |
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Chromosome: | 22 (NC_000022.11) | Locus: | N/A |
HUGO Symbol: | GSTT1 | Full Name: | glutathione S-transferase theta 1 |
Exons: | 5 | Introns: | 4 |
Description:
GSTT1 is a member of the glutathione S-transferase (GST) family of detoxification enzymes, which catalyse conjugation reactions between the reduced form of glutathione (a nucleophile) and a variety of electrophilic compounds, such as environmental toxins and carcinogens. The glutathione system protects cells against damage from oxidative stress by reducing oxygen-free radicals. As oxidative stress would promote sickling of HbS, genetic polymorphisms of GSTs are expected to modulate the phenotype and/or severity of sickle cell disease (SCD). GSTs are encoded by polymorphic genes divided into five classes: α, ζ, μ, π, and θ. The GSTT1 gene encodes a GST that belongs to the θ class.
The null GSTT1 genotype has been linked with carcinogenesis, as well as with an increased risk of developing SCD. It also associated with hemolysis/hepatic (i.e. total and indirect bilirubin levels) laboratory markers in SCA patients treated with hydroxyurea.
The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants.
Synonyms: N/A
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Strange RC, Spiteri MA, Ramachandran S, Fryer AA, Glutathione-S-transferase family of enzymes., Mutat. Res. , 482(1), 21-6, 2001 PubMed
- Abu-Duhier F, Mir R, GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia., Hematology , 2016 PubMed
- Yahouédéhou SCMA, Carvalho MOS, Oliveira RM, Santiago RP, da Guarda CC, Carvalho SP, Ferreira JRD, Aleluia MM, Adorno EV, Gonçalves MS, Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters., Dis. Markers, 2018(0), 6105691, 2018 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2017-01-24 10:14:58 | The IthaGenes Curation Team | Created |
2 | 2018-05-03 18:47:54 | The IthaGenes Curation Team | Reviewed. Gene comment added. |
3 | 2020-09-17 10:52:09 | The IthaGenes Curation Team | Reviewed. Reference added. Comment updated. |
4 | 2020-09-17 10:55:54 | The IthaGenes Curation Team | Reviewed. |