GeneID: 214

Description:
This gene encodes cyclin D3, a member of the family of D-type cyclins with critical functions in cell cycle regulation. D-type cyclins are core components of the cell cycle apparatus and are induced by mitogen stimulation. D-cyclins form a complex with and function as a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. These D-cyclin/CDK complexes interact with and phosphorylate the retinoblastoma tumor suppressor protein (Rb) and Rb-related p107 and p130 proteins, resulting in the release of E3F transcription factors that promote cell cycle G1/S transition. Cyclin D3 plays a critical role in regulating the number of cell divisions during erythroid differentiation, thus controlling erythrocyte size and number. Deregulation of the CCND3 gene has been linked to cancers of haematopoietic origin.

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 2

1. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P, Mouse development and cell proliferation in the absence of D-cyclins., Cell , 118(4), 477-91, 2004 PubMed
2. Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF, Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number., Genes Dev. , 26(18), 2075-87, 2012 PubMed
3. Danjou F, Zoledziewska M, Sidore C, Steri M, Busonero F, Maschio A, Mulas A, Perseu L, Barella S, Porcu E, Pistis G, Pitzalis M, Pala M, Menzel S, Metrustry S, Spector TD, Leoni L, Angius A, Uda M, Moi P, Thein SL, Galanello R, Abecasis GR, Schlessinger D, Sanna S, Cucca F, Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels., Nat. Genet. , 47(11), 1264-71, 2015 PubMed