GeneID: 231

Description:
The gene product is a member of the CRK-associated substrate (Cas) family of scaffold proteins that play an integral role in the assembly of proteins at focal adhesion sites to regulate signalling pathways involved in multiple processes, such as cell migration, adhesion, invasion, and chemotaxis, apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. A polymorphism in this gene associated with fetal haemoglobin levels in patients with sickle cell disease. NEDD9 is a 105-kDa protein with an amino-terminal SH3 domain, a large central region encompassing multiple SH2-binding sites, and a conserved carboxy-terminal domain. Alternative splicing results in multiple transcript variants.

Synonyms: CAS2 , CASL , HEF1 , CAS-L , CASS2

Comments:
N/A

Number of entries/variants: 1

1. Merrill RA, See AW, Wertheim ML, Clagett-Dame M, Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid., Dev. Dyn. , 231(3), 564-75, 2004 PubMed
2. Zhang S, Wu L, Roles of neural precursor cell expressed, developmentally downregulated 9 in tumor-associated cellular processes (Review)., Mol Med Rep , 12(5), 6415-21, 2015 PubMed
3. Shagisultanova E, Gaponova AV, Gabbasov R, Nicolas E, Golemis EA, Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases., Gene , 567(1), 1-11, 2015 PubMed
4. Shaikho EM, Farrell JJ, Alsultan A, Sebastiani P, Steinberg MH, Genetic Determinants of HbF in Saudi Arabian and African Benin Haplotype Sickle Cell Anemia., Am. J. Hematol. , 2017 PubMed