GeneID: 237

Description:
The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein synthesized during myeloid differentiation. It is located in the azurophilic (primary) granules of leukocytes and monocytes, and plays an important role in the host defense system. MPO is produced as a glycosylated precursor peptide, which is subsequently processed into a dimer of two protomers, each composed of a heavy subunit linked through a disulfide bond to a light subunit. Stimulated immune cells release reactive oxygen species (ROS), which are used by MPO to produce hypochlorite (OCl-), which in turn destroys the pathogen. MPO deficiency was associated with a higher occurrence of severe and chronic inflammatory processes. A polymorphism in the MPO gene has been shown to increase the susceptibility to infection in sickle cell anaemia.

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 1

1. Moguilevsky N, Garcia-Quintana L, Jacquet A, Tournay C, Fabry L, Piérard L, Bollen A, Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines., Eur. J. Biochem. , 197(3), 605-14, 1991 PubMed
2. Spickett CM, Jerlich A, Panasenko OM, Arnhold J, Pitt AR, Stelmaszyńska T, Schaur RJ, The reactions of hypochlorous acid, the reactive oxygen species produced by myeloperoxidase, with lipids., Acta Biochim. Pol. , 47(4), 889-99, 2000 PubMed
3. Costa RN, Conran N, Albuquerque DM, Soares PH, Saad ST, Costa FF, Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia., Haematologica , 90(7), 977-9, 2005 PubMed