GeneID: 86

Description:
The protein encoded by this gene is an enzyme that contains both epoxy hydrolase and aminopeptidase activities. The hydrolase site catalyses the conversion of the lipid substrate leukotriene A4 to the lipid proinflammatory mediator leukotriene B4. Leukotrienes are generated from arachidonic acid and LTA4H catalyses the final, rate limiting step in the synthesis of leukotriene B4. The aminopeptidase activity of LTA4H may be involved in the processing of peptides related to inflammation and host-defense. It has been shown to degrade the tri-amino acid peptide proline-glycine-proline (PGP), a known neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Polymorphisms in this gene associated with pulmonary hypertension in sickle cell patients. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 2

1. Thunnissen MM, Nordlund P, Haeggström JZ, Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation., Nat. Struct. Biol. , 8(2), 131-5, 2001 PubMed
2. Ashley-Koch AE, Elliott L, Kail ME, De Castro LM, Jonassaint J, Jackson TL, Price J, Ataga KI, Levesque MC, Weinberg JB, Orringer EP, Collins A, Vance JM, Telen MJ, Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease., Blood , 111(12), 5721-6, 2008 PubMed
3. Wells JM, O'Reilly PJ, Szul T, Sullivan DI, Handley G, Garrett C, McNicholas CM, Roda MA, Miller BE, Tal-Singer R, Gaggar A, Rennard SI, Jackson PL, Blalock JE, An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease., Am. J. Respir. Crit. Care Med. , 190(1), 51-61, 2014 PubMed