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General information for Bangladesh


Bangladesh
Continent: Asia
Capital: Dhaka
Population: 156118464
Area (in sq km): 144000.0

Haemoglobinopathy-specific healthcare policy information for Bangladesh

Healthcare policyComment/InfoReference
Prevention programme: No[PMID: 28521805]
SCD newborn screening: No[PMID: 28521805]
Prenatal screening: Yes (Regional)PND at Dhaka Shishu (Children) Hospital thalassaemia centre since 2014.
Antenatal screening: No[PMID: 25821805]
Haemoglobinopathies patient registry: Yes (Regional)Centre-based.
Dedicated treatment centres: Yes (Regional)E.g.: Thalassaemia Foundation Hospital in Dhaka.[PMID: 28521805]
Blood transfusion availability: Yes (Regional)[PMID: 28521805]
Iron chelation availability: Yes (Regional)[PMID: 28521805]
MRI facilities: No
Patient associations: Yes (National)E.g.: Bangladesh Thalassaemia Samity; Bangladesh Thalassaemia Foundation; Lab One Foundation of Thalassaemia; Thalassaemia Welfare Centre.
Genetic counselling: Yes (Regional)

Prevalence and incidence of major haemoglobinopathies in Bangladesh

HaemoglobinopathyComment/InfoReference
Prevalence of β-thalassaemia carriers: 4.1 % of the population[PMID: 27040959]
Prevalence of sickle cell disease carriers: 1 % of the populationFrom: Thalassaemia Reports 2012, TIF Pan-Asian Conference.
Prevalence of Hb E carriers: 6.1 % of the populationIn tribal population at hill tract area at Chittagong & Bandarban District is about 41.7%.[PMID: 27040959]
Expected incidence of β-thalassaemia: 5477 expected affected births/year[PMID: 24672827]
Incidence of sickle cell disease: 16 affected births/yearMedian value estimated using statistical model and demographic data.[PMID: 23103089]
Known β-thalassaemia patients: 6880 patients[PMID: 24672827]

Mutation frequencies in Bangladesh

Overview (most frequent mutations with their observed average values and range)

β-locus
CD 26 GAG>AAG [Glu>Lys] (HbE): 40.20 % IVS I-5 (G>C): 39.10 %
CD 41/42 (-TTCT or -CTTT): 4.30 %CD 30 (G>C) or IVS I (-1) AGG>ACG (Arg>Thr) (Hb Monroe): 3.50 %

Detailed mutation frequencies

Entry IDLocusRegionEthnic GroupPopulation TypeSample SizeStudy period (from)Study period (to)ReferenceComments
14213β-locusChittagongBangladeshiPatients256201526402558Frequencies are shown for beta-globin gene mutations. Study samples were acquired from the Thalassaemia Welfare Centre and originated from different areas of Chittagong.

Organisations in Bangladesh

A list of all organisations in Bangladesh stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page

NameDepartmentOrganisation type
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Research Center

Microattributions

A/AContributor(s)DateComments
1Rahman, Hafizur2016-11-27Information on healthcare policies and the status of major haemoglobinopathies reviewed and updated.

To provide new epidemiological information and/or report mistakes, please return the completed IthaMaps Submission Form to ithanet@ithanet.eu or use the Contact Us form.

Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Future events

  • Towards Transformative Therapies for Sickle Cell Disease
  • Ninth International Leaders in Biobanking Congress
  • 14th International Conference on Thalassaemia & Haemoglobinopathies & the 16th TIF International Conference for Patients & Parents
  • 5th Annual Advances in Prenatal Molecular Diagnostics
  • PGD and PGS: past, present and future. A celebration Campus event to mark the 20th anniversary of the PGD Consortium

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