Iron regulatory protein

(IRPs); proteins which excert post-transcriptional control of iron homeostasis, generally by binding to control elements (iron responsive elements) in the mRNA of proteins involved in uptake, storage, and use of iron

Description
The function of IRPs (such as IRP1 and IRP2)is influenced by numerous factors, including iron, nitric oxide, oxidative stress and phosphorylation. They may also provide a link between iron availability and cellular citrate use. There is diversity in IRP function in there response to effectors and in their selective binding of specific target mRNAs.