Bone marrow transplantation

grafting of bone marrow stem cells; of value in aplastic anemia, primary immunodeficiency, acute leukemia, lymphoma and other hemopoietic malignancies of bad prognosis (following total body irradiation and chemotherapy as a conditioning regimen to destroy the autologous hemopoietic stem cells), in homozygous thalassemia or sickle cell disease, or severe double heterozygous hemoglobinopathies, and in more controversial cases, such as multiple sclerosis and St. Louis Encephalitis