Lactate dehydrogenase

name for a number of enzymes, including: L-lactate dehydrogenase (cytochrome), D-lactate dehydrogenase (cytochrome), L-lactate dehydrogenase, and D-lactate dehydrogenase

Description
The first two enzymes transfer hydrogen to ferricytochrome c or to cytochrome b2, the last two enzymes transfer it to NAD+, in catalyzing the oxidation of lactate to pyruvate; the isozyme distribution of heart and muscle lactate dehydrogenase is of significant diagnostic use in cases of myocardial infarction; a deficiency of a subunit will result in myoglobinuria after intense exercise. The serum levels of LDH increase in case of hemolysis or tissue necrosis. Syn lactic acid dehydrogenase