Hemoglobin E

(HbE); the probably most common structural hemoglobin variant with thalassaemic properties in the world population, reaching its highest frequency in eastern Thailand and Laos

Description
HbE is not only a structural variant, but is also synthesized inefficiently compared to HbA, causing a clinical phenotype of a mild form of β-thalassemia. The interaction of HbE with mutations causative for β-thalassemia results in thalassemia phenotypes ranging from mild forms of thalassemia intermedia to conditions indistinguishable from thalassemia major; See hemoglobin