Spherocyte

an erythrocyte shaped like a sphere rather than the usual biconcave disk

Description
Spheroid erythrocytes are removed from the blood by the spleen, are less flexible, more prone to osmotic and mechanical damage, and have a smaller surface area than biconcave erythrocytes. They occur as the predominant erythrocyte type in spherocytoses, such as hereditary spherocytosis (commonly caused by erythrocyte cytoskeletal defects) or immune-mediated hemolytic anemias, where the activity of the spleen leads to widespread auto-hemolysis.