Superoxide dismutase

an enzyme that catalyzes the dismutation reaction, 2 O2- + 2 H+ -> H2O2 + O2

Description
In human, two main nuclear-encoded SOD metalloenzymes are expressed, the mitochondrial Fe/Mn SOD2 and the cytosolic Cu/Zn SOD1. Both enzymes are involved in the removal of reactive oxygen species. A deficiency of the SOD1-gene product is associated with amyotrophic lateral sclerosis (ALS).