Insulin receptor substrate-1

IRS-1; a cytoplasmic protein that is a direct substrate of the activated insulin receptor kinase

Description
Insulin exposure results in the rapid phosphorylation of IRS-1 at multiple tyrosine residues. Its phosphorylated sites associate at high affinity with certain cellular proteins. IRS-1 thus acts as an adaptor molecule that links the receptor kinase to various cellular activities regulated by insulin. IRS-1 is also phosphorylated after stimulation by insulin-like growth factor-1 and several interleukins.