Thrombotic thrombocytopenic purpura

(TTP); a rare disorder of the blood coagulation system, leading to hemolysis and organ damage through increased coagulation and mechanic disruption of erythrocytes.

Description
A key factor in TTP is defective breakdown of von-Willebrand factor (vWF), which cross-links thrombocytes, blood clots, and the walls of blood vessels, and in TTP leads to occlusions and shear stress in the microvasculature See schistocyte Syn Moschcowitz disease