GeneID: 101


Common Name: STARD13 Type: Gene
Chromosome: 13 (NC_000013.11) Locus: NG_029752.2 (STARD13)
HUGO Symbol: STARD13 Full Name: StAR related lipid transfer domain containing 13
Exons: 14 Introns: 13

STARD13 belongs to a family of proteins that contain a steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain implicated in lipid metabolism, lipid trafficking and cell signalling. The encoded protein is a member of the RhoGAP subfamily and functions as a major regulator of RhoGTPases, which play critical roles in actin cytoskeletal organization, cell cycle progression, cell proliferation and cell motility. STARD13 contains a sterile α-motif (SAM) for protein-protein interaction, a GTPase-activating protein (GAP) domain and a conserved START domain. STARD13 exhibits GAP activity towards the small RhoGTPases, RhoA and Cdc42, thereby inactivating them. It acts as a tumor suppressor in hepatoma cells. Polymorphisms in this gene associated with acute chest syndrome and osteonecrosis in sickle cell patients. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Synonyms: DLC2 , GT650 , ARHGAP37 , LINC00464


Number of entries/variants: 3


Publications / Origin

  1. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH, Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis., Blood , 106(1), 372-5, 2005
  2. Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, Ng IO, Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity., Proc. Natl. Acad. Sci. U.S.A. , 102(42), 15207-12, 2005
  3. Alpy F, Tomasetto C, Give lipids a START: the StAR-related lipid transfer (START) domain in mammals., J. Cell. Sci. , 118(0), 2791-801, 2005
  4. Fertrin KY, Costa FF, Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment., Expert Rev Hematol , 3(4), 443-58, 2010
Created on 2016-04-27 11:15:03, Last reviewed on (Show full history)

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