GeneID: 120
Names
Common Name: | TNF | Type: | Gene |
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Chromosome: | 6 (NC_000006.12) | Locus: | NG_007462.1 (TNF) |
HUGO Symbol: | TNF | Full Name: | tumor necrosis factor |
Exons: | 4 | Introns: | 3 |
Description:
The encoded protein is a potent pro-inflammatory cytokine, part of the tumor necrosis factor (TNF) superfamily, derived predominantly from activated macrophages. It acts on various signalling pathways through specific cell surface receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR to regulate NF-kB activation of inflammation, stress-activated protein kinases, and apoptotic pathways. It functions mainly in the containment of local infection and is involved in the regulation of several biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. It has also been implicated in noninfectious inflammatory diseases, including rheumatoid arthritis, osteoarthritis, atheroschlerosis, insulin resistance, Alzheimer's disease and cancer. Polymorphisms in this gene associated with stroke in sickle cell patients.
Synonyms: DIF , TNFA , TNFSF2 , TNLG1F , TNF-alpha
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Hoppe C, Klitz W, Cheng S, Apple R, Steiner L, Robles L, Girard T, Vichinsky E, Styles L, , Gene interactions and stroke risk in children with sickle cell anemia., Blood , 103(6), 2391-6, 2004
- Hoppe C, Klitz W, D'Harlingue K, Cheng S, Grow M, Steiner L, Noble J, Adams R, Styles L, , Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia., Stroke , 38(8), 2241-6, 2007
- Zhang JM, An J, Cytokines, inflammation, and pain., Int Anesthesiol Clin , 45(2), 27-37, 2007
- Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011
- Schulte W, Bernhagen J, Bucala R, Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view., Mediators Inflamm. , 2013(0), 165974, 2013
A/A | Date | Curator(s) | Comments |
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1 | 2016-04-27 15:12:26 | The IthaGenes Curation Team | Created |