GeneID: 132
Names
| Common Name: | PLA2G4D-PLA2G4F | Type: | Intergenic Region |
|---|---|---|---|
| Chromosome: | 15 (NC_000015.10) | Locus: | N/A |
| HUGO Symbol: | PLA2G4D-PLA2G4F | Full Name: | N/A |
| Exons: | N/A | Introns: | N/A |
Description:
PLA2G4D and PLA2G4F belong to the family of cytosolic phospholipase A2 (cPLA2) enzymes, which catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids in the plasma membrane to produce free fatty acids and lysophospholipids. The cPLA2 enzymes consist of a Ca2+-dependent lipid binding domain and a catalytic α/β hydrolase domain. They are regulated through phosphorylation by mitogen-activated protein kinases. They are involved in various cellular processes, such as hemodynamic regulation and inflammatory response. Polymorphisms in this intergenic region (PLA2G4D-PLA2G4F) associated with HbF levels in sickle cell patients.
Synonyms: N/A
Comments:
N/A
Number of entries/variants: 1
External Links
No available links
IthaScore
Publications / Origin
- Ohto T, Uozumi N, Hirabayashi T, Shimizu T, Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}., J. Biol. Chem. , 280(26), 24576-83, 2005
- Burke JE, Dennis EA, Phospholipase A2 structure/function, mechanism, and signaling., J. Lipid Res. , 50(0), S237-42, 2009
- Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS, A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease., Exp. Biol. Med. (Maywood) , 2016