GeneID: 141
Names
| Common Name: | MET | Type: | Gene |
|---|---|---|---|
| Chromosome: | 7 (NC_000007.14) | Locus: | NG_008996.1 (MET) |
| HUGO Symbol: | MET | Full Name: | MET proto-oncogene, receptor tyrosine kinase |
| Exons: | 21 | Introns: | 20 |
Description:
This gene encodes the proto-oncogene MET, a member of the receptor tyrosine kinase (RTK) family of proteins. RTKs act through several signal-transduction cascades to regulate important cellular processes in mammalian development, cell function and tissue homeostasis. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. MET binds to hepatocyte growth factor and plays a key role in cell proliferation, cell motility and cell cycle progression. MET dysregulation is linked to cancer development, with mutations in this gene associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Polymoprhisms in this gene associated with stroke in sickle cell patients.
Synonyms: DFNB97 , HGFR , RCCP2
Comments:
N/A
Number of entries/variants: 2
Publications / Origin
- Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005
- Organ SL, Tsao MS, An overview of the c-MET signaling pathway., Ther Adv Med Oncol , 3(1), S7-S19, 2011