GeneID: 173
Names
| Common Name: | OR51B2 | Type: | Pseudogene |
|---|---|---|---|
| Chromosome: | 11 (NC_000011.10) | Locus: | N/A |
| HUGO Symbol: | OR51B2 | Full Name: | olfactory receptor family 51 subfamily B member 2 (gene/pseudogene) |
| Exons: | 1 | Introns: | N/A |
Description:
Olfactory receptors (ORs) are members of a large family of G-protein-coupled receptors (GPCR) that transverse the membrane seven times and are located on the sensory neurons of nasal epithelium. The OR gene family is the largest in the genome and exists as clusters of genes in specific genomic locations. ORs bind to odorant molecules and transduce signals via a G protein, in turn activating downstream effector molecules that trigger the perception of smell. The olfactory system is highly discriminating and each OR can be activated by multiple odorants of similar structure. The ORs are grouped into subfamilies based on the type of odorant structure detected. The nomenclature assigned to the OR genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. The β-globin gene locus is surrounded by a large cluster of OR genes.
Synonyms: OR51B1P
Comments:
N/A
Number of entries/variants: 7
Publications / Origin
- Malnic B, Godfrey PA, Buck LB, The human olfactory receptor gene family., Proc. Natl. Acad. Sci. U.S.A. , 101(8), 2584-9, 2004
- Niimura Y, Nei M, Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates., J. Hum. Genet. , 51(6), 505-17, 2006
- Nuinoon M, Makarasara W, Mushiroda T, Setianingsih I, Wahidiyat PA, Sripichai O, Kumasaka N, Takahashi A, Svasti S, Munkongdee T, Mahasirimongkol S, Peerapittayamongkol C, Viprakasit V, Kamatani N, Winichagoon P, Kubo M, Nakamura Y, Fucharoen S, A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E., Hum. Genet. , 127(3), 303-14, 2010