GeneID: 203
Names
| Common Name: | OPCML | Type: | Gene |
|---|---|---|---|
| Chromosome: | 11 (NC_000011.10) | Locus: | NG_012107.1 (OPCML) |
| HUGO Symbol: | OPCML | Full Name: | opioid binding protein/cell adhesion molecule like |
| Exons: | 8 | Introns: | 7 |
Description:
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded pre-protein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. It is probably involved in cell contact. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. Polymorphisms in this gene associated with HbF levels in individuals with sickle cell disease.
Synonyms: OPCM , OBCAM , IGLON1
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Mtatiro SN, Singh T, Rooks H, Mgaya J, Mariki H, Soka D, Mmbando B, Msaki E, Kolder I, Thein SL, Menzel S, Cox SE, Makani J, Barrett JC, Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania., PLoS ONE , 9(11), e111464, 2014