GeneID: 274

Description:
The CDHR3 gene encodes cadherin-related family member 3, a related member of the cadherin family of transmembrane proteins. Cadherins possess Ca2+-dependent tandemly repeated extracellular domains that mediate cell adhesion processes, such as cell-cell interactions, cell signalling, epithelial polarity and tissue differentiation. CDHR3 is predominantly expressed in ciliated airway epithelial cells, is a recognized receptor for rhinovirus-C entry into host cells and has been identified as a susceptibility locus for severe respiratory illnesses and asthma hospitalizations. Cadherins (specifically, E-cadherin) play an important role in the maturation of erythroid precursors, while evidence indicates that the level of Hb F synthesis varies during erythroid development and maturation. A variation in CDHR3 associated with Hb F response to hydroxyurea in sickle cell disease cohorts.

Synonyms: "FLJ44366 , FLJ23834 , CDH28"

Comments:
N/A

Number of entries/variants: 1

1. Papayannopoulou T, Kalmantis T, Stamatoyannopoulos G, Cellular regulation of hemoglobin switching: evidence for inverse relationship between fetal hemoglobin synthesis and degree of maturity of human erythroid cells., Proc. Natl. Acad. Sci. U.S.A., 76(12), 6420-4, 1979 PubMed
2. Armeanu S, MÜller CA, Klein G, Involvement of E-cadherin in the Development of Erythroid Cells; Subject Heading., Hematology, 5(4), 307-316, 2000 PubMed
3. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
4. Bochkov YA, Watters K, Ashraf S, Griggs TF, Devries MK, Jackson DJ, Palmenberg AC, Gern JE, Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication., Proc. Natl. Acad. Sci. U.S.A., 112(17), 5485-90, 2015 PubMed
5. Watters K, Palmenberg AC, CDHR3 extracellular domains EC1-3 mediate rhinovirus C interaction with cells and as recombinant derivatives, are inhibitory to virus infection., PLoS Pathog., 14(12), e1007477, 2018 PubMed