GeneID: 278
Names
Common Name: | MYBBP1A | Type: | Gene |
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Chromosome: | 17 (NC_000017.11) | Locus: | NG_047119.1 (MYBBP1A) |
HUGO Symbol: | MYBBP1A | Full Name: | MYB binding protein 1a |
Exons: | 27 | Introns: | 26 |
Description:
The MYBBP1A gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the MYB proto-oncogene protein. MYB is predominantly expressed in immature haemopoietic cells where it plays an important role in haemopoietic cell proliferation and differentiation, and has been recognized as an important QTL in the modulation of Hb F gene expression. MYBBP1A is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. A variation in MYBBP1A associated with Hb F response to hydroxyurea in sickle cell disease cohorts.
Synonyms: P160 , PAP2 , FLJ37886 , Pol5
Comments:
N/A
Number of entries/variants: 1
IthaScore
Publications / Origin
- Mori S, Bernardi R, Laurent A, Resnati M, Crippa A, Gabrieli A, Keough R, Gonda TJ, Blasi F, Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor., PLoS ONE, 7(10), e39723, 2012
- Hochstatter J, Hölzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Längst G, Németh A, Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA., J. Biol. Chem., 287(29), 24365-77, 2012
- Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014
- Wang X, Angelis N, Thein SL, MYB - A regulatory factor in hematopoiesis., Gene, 665(0), 6-17, 2018
A/A | Date | Curator(s) | Comments |
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1 | 2019-09-26 09:20:01 | The IthaGenes Curation Team | Created |