GeneID: 283

Description:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) family of membrane-anchored proteins that have important roles in cell adhesion, migration, proteolysis and signalling. ADAM9 is among those proteins that have a catalytic-site consensus sequence (HEXXH) in their metalloprotease domain, hence predicted to be catalytically active. Its cytoplasmic domain contains Pro-rich motifs, which act as binding sites for SH3-domain containing proteins. It has been implicated in heparin-binding EGF-like growth factor shedding, in the processing of the amyloid precursor protein, and in the regulation of cell motility by binding to α6β1 integrin. It contributes to heart development. It associated with diastolic dysfunction in patients with sickle cell disease (SCD) in spite of conflicting evidence in a pre-clinical SCD mouse model.

Synonyms: MCMP , MDC9 , CORD9 , Mltng

Comments:
N/A

Number of entries/variants: 0

1. Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S, Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein., Biochem. J., 343(0), 371-5, 1999
2. Nath D, Slocombe PM, Webster A, Stephens PE, Docherty AJ, Murphy G, Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility., J. Cell. Sci., 113(0), 2319-28, 2000
3. Edwards DR, Handsley MM, Pennington CJ, The ADAM metalloproteinases., Mol. Aspects Med., 29(5), 258-89, 2008
4. Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF, Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease., PLoS ONE , 11(9), e0163013, 2016