GeneID: 287
Names
Common Name: | SULT2B1 | Type: | Gene |
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Chromosome: | 19 (NC_000019.10) | Locus: | NG_029063.1 (SULT2B1) |
HUGO Symbol: | SULT2B1 | Full Name: | sulfotransferase family 2B member 1 |
Exons: | 7 | Introns: | 6 |
Description:
The human hydroxysteroid sulfotransferase (SULT) 2B1 gene, a member of the cytosolic SULT gene superfamily, encodes 2 isoforms, SULT2B1a and SULT2B1b. SULT2B1b catalyzes the sulfonation of 3-beta hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation. The SULT2B1 gene associated with diastolic dysfunction in patients with sickle cell disease (SCD) in spite of conflicting evidence in a pre-clinical SCD mouse model.
Synonyms: HSST2 , ARCI14
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Ji Y, Moon I, Zlatkovic J, Salavaggione OE, Thomae BA, Eckloff BW, Wieben ED, Schaid DJ, Weinshilboum RM, Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics., J. Pharmacol. Exp. Ther., 322(2), 529-40, 2007
- Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF, Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease., PLoS ONE , 11(9), e0163013, 2016
A/A | Date | Curator(s) | Comments |
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1 | 2019-09-30 14:21:45 | The IthaGenes Curation Team | Created |