GeneID: 291

Description:
Cortexin domain containing 2 (CTXND2) is a long non-coding RNA (lncRNA). lncRNAs play a role in the regulation of gene expression. Cortexin is a neuron-specific membrane protein and variations in CTXND2 have been associated with neoplastic disease. A variation in this gene has been associated with acute chest syndrome (ACS) in cohorts with sickle cell disease. ACS is a form of acute lung injury caused by vaso-occlusion within the pulmonary microvasculature. Etiologies either trigger vaso-occlusion (e.g., infection, asthma, hypoventilation) or are a result of vaso-occlusion (e.g., bone marrow and fat emboli).

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 1

1. Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
3. Ransohoff KJ, Wu W, Cho HG, Chahal HC, Lin Y, Dai HJ, Amos CI, Lee JE, Tang JY, Hinds DA, Han J, Wei Q, Sarin KY, Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma., Oncotarget, 8(11), 17586-17592, 2017 PubMed