GeneID: 324
Names
| Common Name: | MIR155 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 21 (NC_000021.9) | Locus: | NR_030784.1 (MIR155) |
| HUGO Symbol: | MIR155 | Full Name: | microRNA 155 |
| Exons: | 1 | Introns: | N/A |
Description:
MicroRNAs (miRNAs) are small (~22 nt) non-coding RNAs involved in post-transcriptional regulation of gene expression by targeting mRNAs for cleavage or translational repression. miRNAs are transcribed by RNA polymerase II as long primary miRNA transcripts (pri-miRNA), which are sequentially cropped by two ribonuclease III (RNase III) enzymes, Drosha and Dicer. The resulting mature miRNA is then loaded into the RNA induced silencing complex (RISC) where it directs the complex to target mRNAs. The miRNA pathway plays an essential role in the development and/or function of most tissues in the body. Upregulation of miR-155 has been shown to enhance the phagocytic activity of β‑thalassemia/HbE monocytes and mediate the clearance or destruction of abnormal red blood cells, possibly via regulation of its target BACH-1 that is involved in phagocytic function.
Synonyms: MIRN155 , hsa-mir-155
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Hammond SM, An overview of microRNAs., Adv. Drug Deliv. Rev., 87(0), 3-14, 2015
- Hasan KN, Sufian A, Mazumder AK, Khaleque MA, Rahman M, Akhteruzzaman S, A Novel Pathogenic β-Thalassemia Mutation Identified at Codon 8 (: c.27delG) in a Bangladeshi Family Acquired ., Hemoglobin, 43(3), 162-165, 2019