GeneID: 341

Description:
HLA-DOA (major histocompatibility complex, class II, DO alpha) and HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) genes belong to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB, called HLA-DO, which is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. HLA-DPA1 is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Genetic variance in the HLA-DOA-HLA-DPA1 intergenic region associated with haematological parameters (e.g., platelet count).

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 1

1. Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, Takahashi A, Matsuda K, Kubo M, Lee J, Kim BJ, Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach., Biomed Res Int , 2015(0), 914965, 2015 PubMed