GeneID: 354
Names
| Common Name: | HDAC2 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 6 (NC_000006.12) | Locus: | NM_001527.4 (HDAC2) |
| HUGO Symbol: | HDAC2 | Full Name: | histone deacetylase 2 |
| Exons: | 14 | Introns: | 13 |
Description:
The protein encoded by this gene belongs to the histone deacetylase (HDAC) family. Members of this family participate in large complexes that act to regulate gene transcription via modification of acetylation marks on lysine residues in histones. Removal of the acetyl groups facilitates tighter packing of chromatin (heterochromatin formation) leading to transcriptional repression. HDAC2 belongs to the class I HDACs (HDSC1, 2, 3, and 8), which are expressed in most cell types with key roles in cellular differentiation and developmental processes. HDAC2 forms part of the NuRD (nucleosome remodelling and deacetylating) complex, which is implicated in HbF control. Inhibition of HDAC2 activates fetal γ-globin gene expression in human adult erythroid cells. The p38 MAPK signalling pathway and GATA2 erythroid transcription factor are implicated in HDAC inhibition-mediated γ-globin induction. HDAC inhibitor drugs hold great promise for the treatment of sickle cell disease and beta-thalassaemia.
Synonyms: HD2 , RPD3 , YAF1 , KDAC2
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB, Histone deacetylases (HDACs): characterization of the classical HDAC family., Biochem. J., 370(0), 737-49, 2003
- Witt O, Monkemeyer S, Rönndahl G, Erdlenbruch B, Reinhardt D, Kanbach K, Pekrun A, Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin., Blood, 101(5), 2001-7, 2003
- Johnson J, Hunter R, McElveen R, Qian XH, Baliga BS, Pace BS, Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid., Cell. Mol. Biol. (Noisy-le-grand), 51(2), 229-38, 2005
- Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL, Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease., Proc. Natl. Acad. Sci. U.S.A., 107(28), 12617-22, 2010
- Esrick EB, McConkey M, Lin K, Frisbee A, Ebert BL, Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation., Am. J. Hematol., 90(7), 624-8, 2015
- Shearstone JR, Golonzhka O, Chonkar A, Tamang D, van Duzer JH, Jones SS, Jarpe MB, Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2., PLoS ONE, 11(4), e0153767, 2016
- Sher F, Hossain M, Seruggia D, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, Kurita R, Nakamura Y, Fujiwara Y, Wolfe SA, Pinello L, Maeda T, Kentsis A, Orkin SH, Bauer DE, Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis., Nat Genet, 51(7), 1149-1159, 2019