GeneID: 356

Description:
The protein encoded by this gene is a member of the STAT (Signal Transducers and Activators of Transcription) protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The JAK-STAT signal transducing pathway mediates the effect of several cytokines including IL6, which is a negative regulator of globin gene expression during megakaryocytic differentiation. STAT3β is a truncated version of STAT3α, is transcriptionally active and binds to a STAT3 motif (TTCTGGAA) in the 5' UTR of γ-globin genes to silence their transcription. Similar STAT3-like binding sites are found in other β-like globin genes, implicating STAT3 gene in globin gene regulation. The STAT3 motif is found in close proximity to the GATA1-binding site. STAT3 interacts with GATA-1 at the γ-globin 5’UTR, in turn influencing γ-globin gene expression. GATA-1 acts as a negative regulator of fetal haemoglobin and is essential for survival and terminal maturation of erythroid precursors.

Synonyms: APRF , HIES , ADMIO , ADMIO1

Comments:
N/A

Number of entries/variants: 0

1. Foley HA, Ofori-Acquah SF, Yoshimura A, Critz S, Baliga BS, Pace BS, Stat3 beta inhibits gamma-globin gene expression in erythroid cells., J. Biol. Chem., 277(18), 16211-9, 2002 PubMed
2. Yao X, Kodeboyina S, Liu L, Dzandu J, Sangerman J, Ofori-Acquah SF, Pace BS, Role of STAT3 and GATA-1 interactions in gamma-globin gene expression., Exp. Hematol., 37(8), 889-900, 2009 PubMed