GeneID: 360

Description:
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The HLA-DQB1 gene has several alleles, which associated with response to severe infections in sickle cell disease (DQB1*03 and DQB1*06) and alloimmunisation in polytransfused patients with sickle cell anaemia (DQB1*03).

Synonyms: IDDM1 , CELIAC1 , HLA-DQB

Comments:
N/A

Number of entries/variants: 0

1. Tamouza R, Neonato MG, Busson M, Marzais F, Girot R, Labie D, Elion J, Charron D, Infectious complications in sickle cell disease are influenced by HLA class II alleles., Hum. Immunol., 63(3), 194-9, 2002 PubMed
2. Rodrigues C, Sell AM, Guelsin GAS, Higa TT, Pagliarini E Silva S, Macedo LC, Sippert EÂ, de Alencar JB, Zanette Â, Acorsi CRL, Castilho L, Visentainer JEL, HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia., Transfus Med, 27(6), 437-443, 2017 PubMed