GeneID: 367
Names
Common Name: | PRMT1 | Type: | Gene |
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Chromosome: | 19 (NC_000019.10) | Locus: | NG_031846.1 (PRMT1) |
HUGO Symbol: | PRMT1 | Full Name: | protein arginine methyltransferase 1 |
Exons: | 11 | Introns: | 10 |
Description:
PRMT1 belongs to the protein arginine methyltransferase (PRMT) enzyme family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. It is involved in a variety of processes, including gene transcription, DNA repair, and signal transduction. It has been associated with human γ-globin gene silencing through association with a protein named friend of PRMT1, aka FOP [GeneID: 349]. PRMT1-mediated dimethyl H4R3 at HS2 of the βLCR has been shown to facilitate histone H3 acetylation on Lys9/Lys14 (AcH3K9/K14) and subsequent transcription of the adult β-globin gene.
Synonyms: ANM1 , HCP1 , IR1B4 , HRMT1L2
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S, Fetal globin expression is regulated by Friend of Prmt1., Blood, 116(20), 4349-52, 2010
- Li X, Hu X, Patel B, Zhou Z, Liang S, Ybarra R, Qiu Y, Felsenfeld G, Bungert J, Huang S, H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation., Blood, 115(10), 2028-37, 2010
A/A | Date | Curator(s) | Comments |
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1 | 2020-03-27 12:32:21 | The IthaGenes Curation Team | Created |