GeneID: 378
Names
| Common Name: | NR3C1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 5 (NC_000005.10) | Locus: | NG_009062.1 (NR3C1) |
| HUGO Symbol: | NR3C1 | Full Name: | nuclear receptor subfamily 3 group C member 1 |
| Exons: | 9 | Introns: | 8 |
Description:
The NR3C1 gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements (GRE) in the promoter of glucocorticoid responsive elements to activate their transcription, and as a modulator of other transcription factors. Found in cytoplasm but transported to the nucleus upon ligand binding. SNVs in NR3C1 gene are associated with increased utilization rate among sickle cell disease (SCD) patients seeking care for acute pain management. NR3C1 may influence the frequency of the crisis pain in SCD.
Synonyms: GR , GCR , GRL , GCCR , GCRST
Comments:
N/A
Number of entries/variants: 3
Publications / Origin
- Jhun EH, Sadhu N, Yao Y, He Y, Molokie RE, Wilkie DJ, Wang ZJ, Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell disease., Pharmacogenomics, 19(13), 1003-1011, 2018