GeneID: 423

Description:
The protein encoded by the DUSP5 gene is a member of the dual-specificity protein phosphatase (DUSP) family. These phosphatases are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues, thus inactivating their target kinases. DUSP5 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. The MAP kinase signaling pathway plays a key role in the regulation of erythropoiesis. Ineffective erythropoiesis due to intramedullary apoptosis and delayed maturation of erythroid progenitor cells is the hallmark of beta-thalassaemia. A significant change in the expression of the DUSP5 gene has been reported in patients with beta-thalassaemia, thus implicating DUSP5 in the pathogenesis of beta-thalassaemia, likely through the MAP kinase pathway.

Synonyms: DUSP , HVH3

Comments:
N/A

Number of entries/variants: 0

1. Elghobashy YA, Assar MF, Mahmoud AA, Monem A Eltorgoman A, Elmasry S, The relation between mitogen activated protein kinase (MAPK) pathway and different genes expression in patients with beta Thalassemia., Biochem Biophys Rep, 24(0), 100836, 2020 PubMed