GeneID: 442
Names
| Common Name: | MAZ | Type: | Gene |
|---|---|---|---|
| Chromosome: | 16 (NC_000016.10) | Locus: | NM_002383.4 (MAZ) |
| HUGO Symbol: | MAZ | Full Name: | MYC associated zinc finger protein |
| Exons: | 5 | Introns: | 4 |
Description:
The Myc-associated zinc finger (MAZ) protein is a DNA-binding transcription factor originally identified as a regulator of MYC gene expression and is frequently found at genomic sites adjacent to CTCF, the chromatin architectural factor, where it contributes to chromatin organization and transcriptional control. In erythroid cells, MAZ binds to promoter regions of globin-related genes and key regulators of erythroid differentiation, and its knockdown has been shown to impair differentiation in primary human erythroid cells. Recent functional studies demonstrate that MAZ occupies the MYB (GeneID: 43) promoter region and activates MYB transcription, thereby indirectly repressing γ-globin expression. Perturbation of MAZ in engineered erythroid cell systems leads to reduced MYB expression and increased fetal hemoglobin (HbF) levels, supporting a MAZ–MYB regulatory axis in globin gene regulation.
Synonyms: PUR1 , ZF87 , Pur-1 , SAF-1 , SAF-2 , SAF-3 , Zif87 , ZNF801 , ,
Comments:
N/A
Number of entries/variants: 0
Publications / Origin
- Xiao T, Li X, Felsenfeld G, The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization., Proc Natl Acad Sci U S A, 118(7), 0, 2021
- Deen D, Butter F, Daniels DE, Ferrer-Vicens I, Ferguson DCJ, Holland ML, Samara V, Sloane-Stanley JA, Ayyub H, Mann M, Frayne J, Garrick D, Vernimmen D, Identification of the transcription factor MAZ as a regulator of erythropoiesis., Blood Adv, 5(15), 3002-3015, 2021
- Lu D, Yang Y, Yang B, Chen D, Zhu M, Huang S, Hu J, Zhu L, Fan W, Xie Y, Song B, Huang P, Sun X, MAZ regulates fetal hemoglobin repression by activating MYB transcription., Sci Rep, 16(1), 1028, 2025