GeneID: 447


Common Name: PRDX1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NM_181697.3 (PRDX1)
HUGO Symbol: PRDX1 Full Name: peroxiredoxin 1
Exons: 6 Introns: 5

The PRDX1 gene encodes a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize hydrogen peroxide (H2O2) and act as a molecular chaperone, respectively. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. PRDX1 gene expression and protein levels were found to be elevated in the reticulocytes and erythrocytes of β-thalassaemia intermedia patients compared to healthy controls. Possible role in protecting red cells from oxidative damage.

Synonyms: PAG , PAGA , PAGB , PRX1 , PRXI , MSP23 , NKEFA , TDPX2 , NKEF-A


Publications / Origin

  1. Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021
Created on 2021-08-19 16:53:31, Last reviewed on (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.