GeneID: 465
Names
Common Name: | RANKL | Type: | Gene |
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Chromosome: | 13 (NC_000013.11) | Locus: | NG_008990.1 (TNFSF11) |
HUGO Symbol: | TNFSF11 | Full Name: | TNF superfamily member 11 |
Exons: | 5 | Introns: | 4 |
Description:
The TNFSF11 gene, also known as RANKL (Receptor Activator of NF-κB ligand), encodes a member of the tumor necrosis factor (TNF) cytokine family and functions as a key factor for osteoclast differentiation and activation by interacting with its specific receptor RANK, expressed in osteoclast precursors and mature osteoclasts, thereby increasing levels of bone resorption. Osteoprotegerin (OPG) [GeneID: 466], a soluble decoy receptor for RANKL, inhibits the RANKL/RANK interaction and arrests osteoclastogenesis and bone loss. TNFSF11 (RANKL) is expressed by T cells during bone metabolism and also functions in the immune system through dendritic cell activation. Studies reported that the RANK/RANKL/OPG system may have an important role in regulating bone metabolism in transfusion-dependent β-thalassemia patients.
Synonyms: RANKL , ODF , OPGL , sOdf , CD254 , OPTB2 , TNLG6B , TRANCE , hRANKL2
Comments:
N/A
Number of entries/variants: 1
Sequence Viewer
Publications / Origin
- Ono T, Hayashi M, Sasaki F, Nakashima T, RANKL biology: bone metabolism, the immune system, and beyond., Inflamm Regen, 40(0), 2, 2020 PubMed
- Youssry I, Saad N, Madboly M, Samy RM, Hamed ST, Tawfik H, Elbatrawy SR, Kaddah N, Abd Elaziz D, Bone health in pediatric transfusion-dependent beta-thalassemia: Circulating osteoprotegerin and RANKL system., Pediatr Blood Cancer, 69(1), e29377, 2022 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2021-12-29 10:16:47 | The IthaGenes Curation Team | Created |
2 | 2021-12-29 10:21:47 | The IthaGenes Curation Team | Reviewed. Text edits. |