GeneID: 480
Names
Common Name: | miR-2355-5p | Type: | Gene |
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Chromosome: | 2 (NC_000002.12) | Locus: | NR_036227.1 (MIR2355) |
HUGO Symbol: | MIR2355 | Full Name: | microRNA 2355 |
Exons: | N/A | Introns: | N/A |
Description:
MicroRNAs (miRNAs), such as MIR2355, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. The miR-2355-5p sequence is a product of MIR2355. Functional studies showed that overexpression of miR-2355-5p in primary CD34+ HSPCs and HUDEP-2 cells correlates with an increase in γ-globin synthesis by suppressing KLF6 [GeneID: 481] expression. miR-2355-5p specifically binds the seed region in the 3'UTR of KLF6. The miR-2355-5p/KLF6 interaction is a candidate therapeutic strategy for the treatment of patients with beta-haemoglobinopathies.
Synonyms: N/A
Comments:
N/A
Number of entries/variants: 0
IthaScore
Publications / Origin
- Cheng Y, Shang X, Chen D, Pang D, Zhao C, Xu X, MicroRNA-2355-5p regulates γ-globin expression in human erythroid cells by inhibiting KLF6., Br J Haematol, 193(2), 401-405, 2021
A/A | Date | Curator(s) | Comments |
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1 | 2022-03-23 12:38:49 | The IthaGenes Curation Team | Created |