GeneID: 481
Names
| Common Name: | KLF6 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 10 (NC_000010.11) | Locus: | NG_012277.1 (KLF6) |
| HUGO Symbol: | KLF6 | Full Name: | Kruppel like factor 6 |
| Exons: | 4 | Introns: | 3 |
Description:
The KLF6 gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator with key roles in several cellular processes and is considered a tumor suppressor. Functional studies showed that KLF6 suppression associates with an increase in γ-globin mRNA and protein levels in primary CD34+ HSPCs and HUDEP-2 cells. This is likely associated with microRNA miR-2355-5p [GeneID: 480], which specifically binds the seed region in the 3'UTR of KLF6. Overexpression of miR-2355-5p suppresses KLF6 and increases γ-globin synthesis. The miR-2355-5p/KLF6 interaction is a candidate therapeutic strategy for the treatment of patients with beta-haemoglobinopathies.
Synonyms: GBF , ZF9 , BCD1 , CBA1 , CPBP , PAC1 , ST12 , COPEB
Comments:
N/A
Number of entries/variants: 0
IthaScore
Sequence Viewer
Publications / Origin
- Cheng Y, Shang X, Chen D, Pang D, Zhao C, Xu X, MicroRNA-2355-5p regulates γ-globin expression in human erythroid cells by inhibiting KLF6., Br J Haematol, 193(2), 401-405, 2021 PubMed
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2022-03-23 12:42:08 | The IthaGenes Curation Team | Created |