GeneID: 491

Names

Common Name:	TOX4	Type:	Gene
Chromosome:	14 (NC_000014.9)	Locus:	N/A
HUGO Symbol:	TOX4	Full Name:	TOX high mobility group box family member 4
Exons:	9	Introns:	8

Description:
TOX4 encodes a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. TOX4 is a component of the PTW/PP1 phosphatase complex and plays a role in the regulation of cell cycle and fate. It is implicated in the control of chromatin structure. Sequence variation in this gene associated with stroke outcomes in patients with sickle cell disease.

Synonyms: LCP1 , MIG7 , C14orf92 , KIAA0737

Comments:
N/A

Number of entries/variants: 1

External Links

NCBI Gene	UniProtKB
HGNC	OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Brewin JN, Rooks H, Gardner K, Senior H, Morje M, Patel H, Calvet D, Bartolucci P, Thein SL, Menzel S, Rees DC, Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC)., Haematologica, 106(6), 1770-1773, 2021 PubMed

Created on 2022-03-29 13:26:32, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2022-03-29 13:26:32	The IthaGenes Curation Team	Created

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