GeneID: 59
Names
Common Name: | ANXA2 | Type: | Gene |
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Chromosome: | 15 (NC_000015.10) | Locus: | N/A |
HUGO Symbol: | ANXA2 | Full Name: | annexin A2 |
Exons: | 13 | Introns: | 12 |
Description:
ANXA2 is a member of the annexin family of calcium-regulated phospholipid-binding proteins. Annexins consist of a conserved α-helical core domain that harbours the calcium-binding motif, and a second divergent domain that undergoes post-translational modifications to specify individual annexin properties. They are involved in a variety of membrane-related functions including exocytosis, endocytosis and membrane trafficking. They play important roles in the regulation of cell growth and in signal transduction pathways. ANXA2 is implicated in bone mineralization and in the generation of the thrombolytic agent plasmin. Polymorphisms in this gene associated with osteonecrosis and stroke in sickle cell patients. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: LIP2 , ANX2
Comments:
N/A
Number of entries/variants: 6
Publications / Origin
- Gillette JM, Nielsen-Preiss SM, The role of annexin 2 in osteoblastic mineralization., J. Cell. Sci. , 117(0), 441-9, 2004
- Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH, Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis., Blood , 106(1), 372-5, 2005
- Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005
- Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011
- Bharadwaj A, Bydoun M, Holloway R, Waisman D, Annexin A2 heterotetramer: structure and function., Int J Mol Sci , 14(3), 6259-305, 2013
A/A | Date | Curator(s) | Comments |
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1 | 2016-04-26 09:55:41 | The IthaGenes Curation Team | Created |
2 | 2016-04-26 09:57:39 | The IthaGenes Curation Team | Reviewed. |
3 | 2016-04-26 10:33:19 | The IthaGenes Curation Team | Reviewed. |
4 | 2016-05-09 14:26:15 | The IthaGenes Curation Team | Reviewed. |