GeneID: 6
Names
Common Name: | ε | Type: | Gene |
---|---|---|---|
Chromosome: | 11 (NC_000011.10) | Locus: | NG_000007.3 (β-locus) |
HUGO Symbol: | HBE1 | Full Name: | hemoglobin subunit epsilon 1 |
Exons: | 3 | Introns: | 2 |
Description:
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic haemoglobin Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic haemoglobins are normally supplanted by fetal, and later, adult haemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3'.
Synonyms: HBE , Epsilon-globin
Comments:
N/A
Number of entries/variants: 43
Publications / Origin
- Gale RE, Clegg JB, Huehns ER, Human embryonic haemoglobins Gower 1 and Gower 2., Nature , 280(5718), 162-4, 1979
- Baralle FE, Shoulders CC, Proudfoot NJ, The primary structure of the human epsilon-globin gene., Cell , 21(3), 621-6, 1980
- Fritsch EF, Lawn RM, Maniatis T, Molecular cloning and characterization of the human beta-like globin gene cluster., Cell , 19(4), 959-72, 1980
A/A | Date | Curator(s) | Comments |
---|---|---|---|
1 | 2014-04-01 14:19:10 | The IthaGenes Curation Team | Created |
2 | 2014-04-11 10:30:59 | The IthaGenes Curation Team | Reviewed. Description, synonyms, references and links added. |
3 | 2016-04-28 10:33:35 | The IthaGenes Curation Team | Reviewed. |
4 | 2016-04-28 11:35:00 | The IthaGenes Curation Team | Reviewed. |