GeneID: 62
Names
Common Name: | ADCY9 | Type: | Gene |
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Chromosome: | 16 (NC_000016.10) | Locus: | NG_011434.1 (ADCY9) |
HUGO Symbol: | ADCY9 | Full Name: | adenylate cyclase 9 |
Exons: | 11 | Introns: | 10 |
Description:
ADCY9 encodes a membrane-bound member of the guanylyl cyclase family of enzymes. The encoded protein belongs to class IV adenylyl cyclases that catalyse the conversion of ATP to cyclic AMP (cAMP) in response to signals from plasma membrane-bound G protein-coupled receptors (GPCR). ADCY9 is part of the signalling pathway of the β2-adrenergic GPCR. cAMP signals to downstream effectors, such as protein kinase A, which activate other kinase cascades that in turn modulate the activity of multiple downstream proteins. Polymorphisms in this gene associated with stroke in sickle cell patients.
Synonyms: AC9 , ACIX
Comments:
N/A
Number of entries/variants: 5
IthaScore
Publications / Origin
- Hurley JH, Structure, mechanism, and regulation of mammalian adenylyl cyclase., J. Biol. Chem. , 274(12), 7599-602, 1999
- Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA, Guanylyl cyclases and signaling by cyclic GMP., Pharmacol. Rev. , 52(3), 375-414, 2000
- Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005
- Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011
A/A | Date | Curator(s) | Comments |
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1 | 2016-04-26 10:45:05 | The IthaGenes Curation Team | Created |
2 | 2016-04-26 11:00:46 | The IthaGenes Curation Team | Reviewed. |