IthaMaps

Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge

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General information for Belgium

Belgium

Continent:	Europe
Capital:	Brussels
Population:	10403000
Area (in sq km):	30510.0

Haemoglobinopathy-specific healthcare policy information for Belgium

Healthcare policy		Comment/Info	Reference
Prevention programme:	No	Premarital/preconception screening is offered upon request.	[PMID: 24921462]
SCD newborn screening:	Yes (Regional)	Universal screening for haemoglobinopathies in Brussels since 1994 and in Liège since 2002. Includes SCD.	[PMID: 33072975]
Prenatal screening:	No	Available for haemoglobinopathies, although not systematically performed.	[PMID: 10321364]
Antenatal screening:	No	Offered upon request.	[PMID: 24980780]
Haemoglobinopathies patient registry:	Yes (National)	E.g., National Sickle Cell Disease Register, National registry of patients with thalassaemia major [ERN-EuroBloodNet_Report on existing registries for RHD_2018]
Rare disease patient registry:	Yes (National)	E.g. Central Registry of Rare Diseases, The Bulgarian genetic registry of monogenic disorders [ERN-EuroBloodNet_Report on existing registries for RHD_2018]
Patient associations:	Yes (National)	E.g.: Association Belge de Thalassémie ASBL.

Prevalence and incidence of major haemoglobinopathies in Belgium

Haemoglobinopathy		Comment/Info	Reference
Prevalence of β-thalassaemia carriers:	0.28 % of the population		[PMID: 24672827]
Prevalence of sickle cell disease carriers:	1.598 % of the population	Neonatal screening in Brussels and Liège regions during 2009–2017. From: doi.org/10.3390/ijns4040037
Prevalence of Hb E carriers:	0.02 % of the population		[PMID: 17365984]
Prevalence of Hb C carriers:	0.02 % of the population		[PMID: 17365984]
Expected incidence of β-thalassaemia:	0 expected affected births/year	Less than 1% expected births.	[PMID: 24672827]
Incidence of sickle cell disease:	29 affected births/year	Median value estimated using statistical model and demographic data.	[PMID: 23103089]
Known β-thalassaemia patients:	100 patients	ENERCA report Aug. 2013
Known sickle cell disease patients:	538 patients	Registered SCD patients in 2018. From: doi.org/10.3390/ijns4040037

Global Burden of Disease data for Belgium

Migration data for Belgium

Mutation frequencies in Belgium

No mutation frequencies are currently available for Belgium

Organisations in Belgium

A list of all organisations in Belgium stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page

Name	Department	Organisation type
Hôpital Erasme		Medical Center
European Organization for Rare Diseases (EURORDIS)		Patient Society
European Society of Human Reproduction and Embryology (ESHRE)		Scientific Society

Microattributions

No microattibutions were provided for Belgium. Please contact us, if you are willing to review existing information or provide new data.

To provide new epidemiological information and/or report mistakes, please register/log in first or use the Contact Us form.

Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Note: The information you provide for the specific country will appear on the IthaMaps website and your contribution will be acknowledged.

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Surname:		Organisation's brief description:
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ORCID

Healthcare Policies

Health-policy	Select one Answer	Comment
Prevention programme
SCD newborn screening
Prenatal screening
Antenatal screening
Haemoglobinopathies patient registry
Rare disease patient registry
Dedicated treatment centres
Blood transfusion availability
Iron chelation availability
MRI facilities
Patient associations
Genetic counselling

Status of major Haemoglobinopathies

In Expected Incidence of β-thalassaemia and sickle cell disease please provide the number of expected affected births/year (without prevention).
In Incidence of β-thalassaemia and sickle cell disease please provide the number of affected births/year (after prevention).

Haemoglobinopathy	Provide value		Comment
Prevalence of β-thalassaemia carriers		% of the population
Prevalence of sickle cell disease carriers		% of the population
Prevalence of α-thalassaemia carriers		% of the population
Prevalence of Hb E carriers		% of the population
Prevalence of Hb C carriers		% of the population
Expected incidence of β-thalassaemia		expected affected births/year
Expected incidence of sickle cell disease		expected affected births/year
Expected incidence of α-thalassaemia		expected affected births/year
Incidence of β-thalassaemia		affected births/year
Incidence of sickle cell disease		affected births/year
Incidence of α-thalassaemia		affected births/year
Known β-thalassaemia patients		patients
Known sickle cell disease patients		patients

Mutation Frequencies

Please provide details about publications reporting mutation frequencies in the country of reference (either country-wide studies or region-specific studies).

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