Welcome to IthaMaps
IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.
IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge
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General information for Cuba
Cuba |
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Haemoglobinopathy-specific healthcare policy information for Cuba
Healthcare policy | Comment/Info | Reference | |
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Prevention programme: | Yes (National) | Screening pregnant women and couples for carrier status as part of the Sickle Cell Anemia Prevention program implemented in 1982 | [PMID: 32335567] |
SCD newborn screening: | No | [PMID: 32335567] | |
Prenatal screening: | Yes (National) | For the diagnosis of SCD genotypes in the fetus. | [PMID: 32335567] |
Antenatal screening: | Yes (National) | Screening of pregnant women as part of the Sickle Cell Anemia Prevention program implemented in 1982. | [PMID: 32335567] |
Genetic counselling: | Yes (National) | As part of the Sickle Cell Anemia Prevention Programetus | [PMID: 32335567] |
Prevalence and incidence of major haemoglobinopathies in Cuba
Haemoglobinopathy | Comment/Info | Reference | |
---|---|---|---|
Prevalence of β-thalassaemia carriers: | 0.75 % of the population | [PMID: 24672827] | |
Prevalence of sickle cell disease carriers: | 3.2 % of the population | %AS varies across provinces from 1.7% to 6.3%. Antenatal testing for SCD during 1982-2018 | [PMID: 32335567] |
Prevalence of Hb E carriers: | 0 % of the population | From: Modell's Haemoglobinopathologist's Almanac. | |
Prevalence of Hb C carriers: | 0.6 % of the population | Screening of pregnant women during 1982-2018. | [PMID: 32335567] |
Expected incidence of β-thalassaemia: | 2 expected affected births/year | [PMID: 24672827] | |
Expected incidence of sickle cell disease: | 39 expected affected births/year | [PMID: 24672827] | |
Incidence of sickle cell disease: | 240 affected births/year | Median value estimated using statistical model and demographic data. | [PMID: 23103089] |
Known sickle cell disease patients: | 4000 patients | [PMID: 24672827] |
Global Burden of Disease data for Cuba
Migration data for Cuba
Mutation frequencies in Cuba
Overview (most frequent mutations with their observed average values and range)
β-locus
CD 41/42 (-CTTT): 34.3 % (6.1 % – 62.5 %) | CD 39 CAG>TAG [Gln>STOP]: 32.93 % (21.1 % – 47.2 %) |
-29 (A>G): 17.4 % (12.5 % – 26.3 %) | IVS I-110 G>A: 9.17 % (7.9 % – 11.1 %) |
Detailed mutation frequencies
Entry ID | Locus | Region | Ethnic Group | Population Type | Sample Size | Study period (from) | Study period (to) | Reference | Comments | |
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23576 | β-locus | Country-wide | Cuban | Carriers and Patients | 82 | 2000 | 10815781 | Frequencies are shown for beta-globin gene mutations. The study samples consisted of European-Cubans, African-Cubans, and Asian-Cubans. | ||
23577 | β-locus | Country-wide | European-Cuban | Carriers and Patients | 36 | 2000 | 10815781 | Frequencies are shown for beta-globin gene mutations. | ||
23578 | β-locus | Country-wide | African-Cuban | Carriers and Patients | 38 | 2000 | 10815781 | Frequencies are shown for beta-globin gene mutations. | ||
23579 | β-locus | Country-wide | Asian-Cuban | Carriers and Patients | 8 | 2000 | 10815781 | Frequencies are shown for beta-globin gene mutations. |
Organisations in Cuba
Organisations in Cuba are currently not available
Microattributions
No microattibutions were provided for Cuba. Please contact us, if you are willing to review existing information or provide new data.
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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.
Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.