Welcome to IthaMaps
IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.
IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge
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General information for Czech Republic
Czech Republic |
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Haemoglobinopathy-specific healthcare policy information for Czech Republic
Healthcare policy | Comment/Info | Reference | |
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SCD newborn screening: | No | SCD is not included in the neonatal screening panel. | [PMID: 33808002] |
Rare disease patient registry: | No | From: RD-Action 2016 report on Rare Disease Activities in the Czech Republic |
Prevalence and incidence of major haemoglobinopathies in Czech Republic
Haemoglobinopathy | Comment/Info | Reference | |
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Prevalence of β-thalassaemia carriers: | 0.12 % of the population | [PMID: 24672827] | |
Prevalence of sickle cell disease carriers: | 0.002 % of the population | [PMID: 24672827] | |
Expected incidence of β-thalassaemia: | 0 expected affected births/year | Less than 1% expected births. | [PMID: 24672827] |
Global Burden of Disease data for Czech Republic
Migration data for Czech Republic
Mutation frequencies in Czech Republic
Overview (most frequent mutations with their observed average values and range)
β-locus
IVS I-1 G>A: 36.15 % (27.1 % – 45.2 %) | IVS I-110 G>A: 11.15 % (5.3 % – 17 %) |
IVS II-1 G>A: 10.55 % (7 % – 14.1 %) | IVS I-6 (T>C): 8.9 % |
Detailed mutation frequencies
Entry ID | Locus | Region | Ethnic Group | Population Type | Sample Size | Study period (from) | Study period (to) | Reference | Comments | |
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23149 | β-locus | Country-wide | Czech | Carriers | 93 | 1991 | 1740317 | Frequencies are shown for beta-globin gene mutations. Study samples were from Prague, Olomouc, Hradec Kralove and Bratislava. | ||
23150 | β-locus | Country-wide | Multi-ethnic | Carriers | 357 | 2002 | 2015 | 26956563 | Frequencies are shown for beta-globin gene mutations. Study samples were acquired from Czech and Slovak haematological centers and were mostly of Czech or Slovak origin. |
Organisations in Czech Republic
A list of all organisations in Czech Republic stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page
Name | Department | Organisation type |
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Masaryk University (MU) | Institute of Computer Science | Research Center, Higher Education |
Microattributions
No microattibutions were provided for Czech Republic. Please contact us, if you are willing to review existing information or provide new data.
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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.
Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.