Welcome to IthaMaps
IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.
IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge
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General information for Laos
 Laos |
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|---|
Haemoglobinopathy-specific healthcare policy information for Laos
| Healthcare policy | Comment/Info | Reference | |
|---|---|---|---|
| Prevention programme: | No | Based on pilot screening programmes. | [PMID: 18414862] |
| SCD newborn screening: | No | Limited or no formal neonatal screening program | [PMID: 33072985] |
| Prenatal screening: | No | [PMID: 27040959] | |
| Antenatal screening: | No | From: Thalassaemia Reports 2012, TIF Pan-Asian Conference. | |
| Haemoglobinopathies patient registry: | No | From: Thalassaemia Reports 2012, TIF Pan-Asian Conference. | |
| Dedicated treatment centres: | No | ||
| Blood transfusion availability: | Yes (Regional) | [PMID: 27040959] | |
| Iron chelation availability: | Yes (Regional) | [PMID: 27040959] | |
| MRI facilities: | No | From: TIF report on South East Asian Nations, Aug. 2013. | |
| Genetic counselling: | No | As part of pilot thalassemia screening program, offered by trained counselors. | [PMID: 29620818] |
Prevalence and incidence of major haemoglobinopathies in Laos
| Haemoglobinopathy | Comment/Info | Reference | |
|---|---|---|---|
| Prevalence of β-thalassaemia carriers: | 6 % of the population | [PMID: 27040959] | |
| Prevalence of α-thalassaemia carriers: | 42 % of the population | TIF report on South East Asian Nations, Aug. 2013 | |
| Prevalence of Hb E carriers: | 18 % of the population | HbE prevalence up to 30% has been reported. | [PMID: 27040959] |
| Expected incidence of β-thalassaemia: | 1106 expected affected births/year | [PMID: 24672827] |
Global Burden of Disease data for Laos
Migration data for Laos
Mutation frequencies in Laos
Overview (most frequent mutations with their observed average values and range)
α-locus
| --SEA: 44.18 % | -α3.7 (type I): 40.7 % |
| CD 142 (TAA>CAA) >172aa (Hb Constant Spring): 8.14 % | -α4.2: 4.65 % |
β-locus
| CD 26 GAG>AAG [Glu>Lys] (HbE): 80.2 % (70 % – 90.4 %) | CD 41/42 (-CTTT): 10.79 % (3.48 % – 18.1 %) |
| -28 (A>G): 9.3 % | CD 17 AAG>TAG [Lys>STOP]: 7.09 % (3.48 % – 10.7 %) |
Detailed mutation frequencies
| Entry ID | Locus | Region | Ethnic Group | Population Type | Sample Size | Study period (from) | Study period (to) | Reference | Comments | |
|---|---|---|---|---|---|---|---|---|---|---|
| 23554 | β-locus | Vientiane | Laotian | Carriers and Patients | 364 | 2021 | 33244864 | Frequencies are shown for beta-globin gene mutations. Study samples were suspected of having thalassemia based on an initial hematological investigation at the Children Hospital, Vientiane. | ||
| 23555 | β-locus | Vientiane | Lao Loum | Carriers and Patients | 115 | 2019 | 31271507 | Frequencies are shown for beta-globin gene mutations and were calculated by Ithanet. | ||
| 23556 | α-locus | Vientiane | Lao Loum | Carriers and Patients | 86 | 2019 | 31271507 | Frequencies are shown for alpha-globin gene mutations and were calculated by Ithanet. |
Organisations in Laos
Organisations in Laos are currently not available
Microattributions
No microattibutions were provided for Laos. Please contact us, if you are willing to review existing information or provide new data.
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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.
Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.