Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge

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  General information for Sri Lanka


Sri Lanka
Continent: Asia
Capital: Colombo
Population: 21513990
Area (in sq km): 65610.0

Haemoglobinopathy-specific healthcare policy information for Sri Lanka

Healthcare policyComment/InfoReference
Prevention programme: Yes (National)National thalassaemia screening programme for school children and young adults (premarital screening) has been in place since 2005.[PMID: 31419232]
Prenatal screening: Yes (Regional)Available since 2005 in the capital city of Colombo.[PMID: 28397548]
Antenatal screening: NoFrom: Thalassaemia Reports 2012, TIF Pan-Asian Conference.
Haemoglobinopathies patient registry: NoThe Thalassaemia eRegistry is a pilot project run at Kurunegala and Anuradhapura Thalassaemia Centres.
Dedicated treatment centres: Yes (Regional)Four regional thalassaemia centres are located in the provinces with the highest burden of disease [From: WHO South-East Asia 2021 report, ISBN: 978-92-9022-851-6]
Blood transfusion availability: Yes (National)Blood Transfusion Services are free of charge for all patients in the country under the National Health Policy [From: WHO South-East Asia 2021 report, ISBN: 978-92-9022-851-6]
Iron chelation availability: Yes (National)Iron chelation is free of charge for all patients in the country under the National Health Policy [From: WHO South-East Asia 2021 report, ISBN: 978-92-9022-851-6]
Patient associations: Yes (National)e.g.: Thalassemia Circle Sri Lanka

  Prevalence and incidence of major haemoglobinopathies in Sri Lanka

HaemoglobinopathyComment/InfoReference
Prevalence of β-thalassaemia carriers: 2.5 % of the population[PMID: 27040959]
Prevalence of sickle cell disease carriers: 1 % of the populationLess than 1%. From: Thalassaemia Reports 2012, TIF Pan-Asian Conference.
Prevalence of Hb E carriers: 2.5 % of the population[PMID: 27040959]
Expected incidence of β-thalassaemia: 64 expected affected births/year[PMID: 24672827]
Incidence of sickle cell disease: 2 affected births/yearMedian value estimated using statistical model and demographic data.[PMID: 23103089]
Known β-thalassaemia patients: 3410 patients[PMID: 24672827]

  Global Burden of Disease data for Sri Lanka

  Migration data for Sri Lanka

Mutation frequencies in Sri Lanka

 Overview (most frequent mutations with their observed average values and range)

 β-locus

IVS I-5 (G>C): 57.05 % (43.8 % – 71.1 %)IVS I-1 G>A: 14.69 % (2.6 % – 27 %)
CD 26 GAG>AAG [Glu>Lys] (HbE): 14.22 % (1.5 % – 43.8 %)CD 121 GAA>CAA [Glu>Gln] (Hb D-Punjab): 6.3 % (0.1 % – 12.5 %)

 Detailed mutation frequencies

Entry IDLocusRegionEthnic GroupPopulation TypeSample SizeStudy period (from)Study period (to)ReferenceComments
22821β-locusAnuradhapuraMulti-ethnicPatients250200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22822β-locusBadullaMulti-ethnicPatients152200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22823β-locusChilawMulti-ethnicPatients88200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22824β-locusColomboMulti-ethnicPatients66200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22825β-locusGalleMulti-ethnicPatients8200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22826β-locusKandyMulti-ethnicPatients80200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22827β-locusKurunegalaMulti-ethnicPatients580200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22828β-locusNegomboMulti-ethnicPatients16200312752111Frequencies are shown for beta-globin gene mutations. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22829β-locusCountry-wideMulti-ethnicPatients1240200312752111Frequencies are shown for beta-globin gene mutations. Study samples were acquired from health clinics in eight major cities of Sri Lanka. The patient population comprised of Sinhalese, Muslims (Moors and Malaysian) and Tamils.
22830β-locusCountry-wideSri LankanCarriers and Patients560200111791873Frequencies are shown for beta-globin gene mutations. The majority of samples studied were patients.

  Organisations in Sri Lanka

Organisations in Sri Lanka are currently not available

 Microattributions

No microattibutions were provided for Sri Lanka. Please contact us, if you are willing to review existing information or provide new data.

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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.