IthaMaps

Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge

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General information for Tunisia

Tunisia

Continent:	Africa
Capital:	Tunis
Population:	10589025
Area (in sq km):	163610.0

Haemoglobinopathy-specific healthcare policy information for Tunisia

Healthcare policy		Comment/Info	Reference
Prevention programme:	No	Screening is targeted towards at risk subjects. From: 2011 WHO Report WHO-EM-NCD-068-E.	[PMID: 26993054]
SCD newborn screening:	No	Pilot NBS study.	[PMID: 34828426]
Prenatal screening:	Yes (National)	From: 2nd MEGMA Conference Proceedings.
Rare disease patient registry:	No	http://africa-rare.org/
Patient associations:	Yes (National)	E.g.: ALPHATT Tunisie
Genetic counselling:	Yes (National)	Provided at the time of diagnosis and follow-up care. From: 2011 WHO Report WHO-EM-NCD-068-E

Prevalence and incidence of major haemoglobinopathies in Tunisia

Haemoglobinopathy		Comment/Info	Reference
Prevalence of β-thalassaemia carriers:	2.21 % of the population		[PMID: 24672827]
Prevalence of sickle cell disease carriers:	1.9 % of the population		[PMID: 24672827]
Prevalence of α-thalassaemia carriers:	7.38 % of the population	Different studies report a prevalence in the range of 2-8%.	[PMID: 23224852]
Prevalence of Hb C carriers:	0.7 % of the population		[PMID: 26633548]
Expected incidence of β-thalassaemia:	20 expected affected births/year		[PMID: 24672827]
Expected incidence of sickle cell disease:	49 expected affected births/year		[PMID: 24672827]
Incidence of sickle cell disease:	81 affected births/year	Median value estimated using statistical model and demographic data.	[PMID: 23103089]
Known β-thalassaemia patients:	742 patients		[PMID: 24672827]
Known sickle cell disease patients:	1526 patients		[PMID: 24672827]

Global Burden of Disease data for Tunisia

Migration data for Tunisia

Mutation frequencies in Tunisia

Overview (most frequent mutations with their observed average values and range)

β-locus

CD 39 CAG>TAG [Gln>STOP]: 45.91 % (27.6 % – 57.6 %)	IVS I-110 G>A: 21.12 % (9.7 % – 41.4 %)
IVS I-2 (T>G): 7.97 % (0.54 % – 24.2 %)	IVS I-1 G>A: 5.32 % (3.3 % – 10.8 %)

Detailed mutation frequencies

Entry ID	Locus	Region	Ethnic Group	Population Type	Sample Size	Study period (to)	Reference	Comments
23580	β-locus	Country-wide	Tunisian	Carriers and Patients	475	2004	15481884	Frequencies are shown for beta-globin gene mutations. Study samples originated from different parts of Tunisia.
23581	β-locus	Country-wide	Tunisian	Carriers and Patients	185	2004	15481885	Frequencies are shown for beta-globin gene mutations. Study samples originated from different parts of Tunisia.
23582	β-locus	North and Northwest	Tunisian	Carriers and Patients	93	2004	15481884	Frequencies are shown for beta-globin gene mutations.
23583	β-locus	Northwest	Tunisian	Carriers and Patients	184	2004	15481884	Frequencies are shown for beta-globin gene mutations.
23584	β-locus	Central west	Tunisian	Carriers and Patients	134	2004	15481884	Frequencies are shown for beta-globin gene mutations.
23585	β-locus	Central east	Tunisian	Carriers and Patients	33	2004	15481884	Frequencies are shown for beta-globin gene mutations.
23586	β-locus	South	Tunisian	Carriers and Patients	29	2004	15481884	Frequencies are shown for beta-globin gene mutations.

Organisations in Tunisia

A list of all organisations in Tunisia stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page

Name	Department	Organisation type
Hopital Charles Nicolle Tunis		Medical Center
Hospital Children Béchir Hamza		Medical Center
Pasteur Institute of Tunis (IPT)	Tunisia Laboratory of molecular and cellular hematology	Research Center, Medical Center, Diagnostic Center

Microattributions

No microattibutions were provided for Tunisia. Please contact us, if you are willing to review existing information or provide new data.

To provide new epidemiological information and/or report mistakes, please register/log in first or use the Contact Us form.

Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Note: The information you provide for the specific country will appear on the IthaMaps website and your contribution will be acknowledged.

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Healthcare Policies

Health-policy	Select one Answer	Comment
Prevention programme
SCD newborn screening
Prenatal screening
Antenatal screening
Haemoglobinopathies patient registry
Rare disease patient registry
Dedicated treatment centres
Blood transfusion availability
Iron chelation availability
MRI facilities
Patient associations
Genetic counselling

Status of major Haemoglobinopathies

In Expected Incidence of β-thalassaemia and sickle cell disease please provide the number of expected affected births/year (without prevention).
In Incidence of β-thalassaemia and sickle cell disease please provide the number of affected births/year (after prevention).

Haemoglobinopathy	Provide value		Comment
Prevalence of β-thalassaemia carriers		% of the population
Prevalence of sickle cell disease carriers		% of the population
Prevalence of α-thalassaemia carriers		% of the population
Prevalence of Hb E carriers		% of the population
Prevalence of Hb C carriers		% of the population
Expected incidence of β-thalassaemia		expected affected births/year
Expected incidence of sickle cell disease		expected affected births/year
Expected incidence of α-thalassaemia		expected affected births/year
Incidence of β-thalassaemia		affected births/year
Incidence of sickle cell disease		affected births/year
Incidence of α-thalassaemia		affected births/year
Known β-thalassaemia patients		patients
Known sickle cell disease patients		patients

Mutation Frequencies

Please provide details about publications reporting mutation frequencies in the country of reference (either country-wide studies or region-specific studies).

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