IthaMaps

Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge

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General information for Taiwan

Taiwan

Continent:	Asia
Capital:	Taipei
Population:	22894384
Area (in sq km):	35980.0

Haemoglobinopathy-specific healthcare policy information for Taiwan

Healthcare policy		Comment/Info	Reference
Prevention programme:	Yes (National)	Based on premarital/preconception screening.	[PMID: 24921462]
SCD newborn screening:	No	SCD is not included in neonatal screening panel [www.hpa.gov.tw] [ISBN 978-986-04-8231-7]
Prenatal screening:	Yes (National)		[PMID: 27891555]
Antenatal screening:	Yes (National)	Since 1993.	[PMID: 20571509]
Haemoglobinopathies patient registry:	No	The registry for catastrophic illness database includes thalassaemia major.	[PMID: 27571924]
Rare disease patient registry:	No	RDs are included in the National Disability Registry administered by the Department of Statistics and Department of Social Welfare.	[PMID: 22940167]
Blood transfusion availability:	Yes (National)	In the context of β-TM, blood transfusion is covered by the National Health Insurance (NIH) system of universal health care.	[PMID: 19814676]
Iron chelation availability:	Yes (National)	In the context of β-TM, iron chelation is covered by the National Health Insurance (NIH) system of universal health care.	[PMID: 19814676]
Patient associations:	Yes (National)

Prevalence and incidence of major haemoglobinopathies in Taiwan

Haemoglobinopathy		Comment/Info	Reference
Prevalence of β-thalassaemia carriers:	2 % of the population		[PMID: 24672827]
Prevalence of α-thalassaemia carriers:	4 % of the population	3-5%	[PMID: 27891555]
Prevalence of Hb E carriers:	0.027 % of the population		[PMID: 24672827]
Expected incidence of β-thalassaemia:	21 expected affected births/year		[PMID: 24672827]
Known β-thalassaemia patients:	400 patients		[PMID: 24672827]

Global Burden of Disease data for Taiwan

Migration data for Taiwan

Mutation frequencies in Taiwan

Overview (most frequent mutations with their observed average values and range)

α-locus

--SEA: 80.85 % (77.4 % – 84.3 %)	--FIL: 9.15 % (5.2 % – 13.1 %)
-α3.7 (type I): 4.28 % (4.05 % – 4.5 %)	--THAI: 2.03 % (1.96 % – 2.1 %)

β-locus

IVS II-654 C>T: 39.05 % (33 % – 50.9 %)	CD 41/42 (-CTTT): 29.63 % (28.5 % – 32.2 %)
-28 (A>G): 18.27 % (10 % – 34 %)	CD 17 AAG>TAG [Lys>STOP]: 7.07 % (2.13 % – 10.7 %)

Detailed mutation frequencies

Entry ID	Locus	Region	Ethnic Group	Population Type	Sample Size	Study period (from)	Study period (to)	Reference	Comments
23441	α-locus	Southern Taiwan	Taiwanese	Carriers	1044	2003	2012	27891555	Frequencies are shown for alpha-globin gene mutations, and were calculated by Ithanet. The study samples were collected from a referral center in southern Taiwan.
23442	β-locus	Southern Taiwan	Taiwanese	Carriers	289	2003	2012	27891555	Frequencies are shown for beta-globin gene mutations, and were calculated by Ithanet. The study samples were collected from a referral center in southern Taiwan.
23443	β-locus	Country-wide	Taiwanese	Carriers	631	1998	2009	21599435	Frequencies are shown for beta-globin gene mutations, and were calculated by Ithanet.
23444	α-locus	Country-wide	Taiwanese	Carriers	1630	1998	2009	21599435	Frequencies are shown for alpha-globin gene mutations, and were calculated by Ithanet.
23445	β-locus	Country-wide	Taiwanese	Carriers	125	1998	2011	23689197	Frequencies are shown for beta-globin gene mutations, and were calculated by Ithanet. Study samples were obtained from a central Taiwan medical center.
23446	β-locus	Country-wide	Taiwanese	Patients	94	1998	2011	23689197	Frequencies are shown for beta-globin gene mutations, and were calculated by Ithanet. Study samples were obtained from a central Taiwan medical center.

Organisations in Taiwan

Organisations in Taiwan are currently not available

Microattributions

No microattibutions were provided for Taiwan. Please contact us, if you are willing to review existing information or provide new data.

To provide new epidemiological information and/or report mistakes, please register/log in first or use the Contact Us form.

Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Note: The information you provide for the specific country will appear on the IthaMaps website and your contribution will be acknowledged.

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Healthcare Policies

Health-policy	Select one Answer	Comment
Prevention programme
SCD newborn screening
Prenatal screening
Antenatal screening
Haemoglobinopathies patient registry
Rare disease patient registry
Dedicated treatment centres
Blood transfusion availability
Iron chelation availability
MRI facilities
Patient associations
Genetic counselling

Status of major Haemoglobinopathies

In Expected Incidence of β-thalassaemia and sickle cell disease please provide the number of expected affected births/year (without prevention).
In Incidence of β-thalassaemia and sickle cell disease please provide the number of affected births/year (after prevention).

Haemoglobinopathy	Provide value		Comment
Prevalence of β-thalassaemia carriers		% of the population
Prevalence of sickle cell disease carriers		% of the population
Prevalence of α-thalassaemia carriers		% of the population
Prevalence of Hb E carriers		% of the population
Prevalence of Hb C carriers		% of the population
Expected incidence of β-thalassaemia		expected affected births/year
Expected incidence of sickle cell disease		expected affected births/year
Expected incidence of α-thalassaemia		expected affected births/year
Incidence of β-thalassaemia		affected births/year
Incidence of sickle cell disease		affected births/year
Incidence of α-thalassaemia		affected births/year
Known β-thalassaemia patients		patients
Known sickle cell disease patients		patients

Mutation Frequencies

Please provide details about publications reporting mutation frequencies in the country of reference (either country-wide studies or region-specific studies).

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