GeneID: 122
Names
| Common Name: | OR51V1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 11 (NC_000011.10) | Locus: | N/A |
| HUGO Symbol: | OR51V1 | Full Name: | olfactory receptor family 51 subfamily V member 1 |
| Exons: | 1 | Introns: | N/A |
Description:
Olfactory receptors (ORs) are members of a large family of G-protein-coupled receptors (GPCR) that transverse the membrane seven times and are located on the sensory neurons of nasal epithelium. The OR gene family is the largest in the genome and exists as clusters of genes in specific genomic locations. ORs bind to odorant molecules and transduce signals via a G protein, in turn activating downstream effector molecules that trigger the perception of smell. The olfactory system is highly discriminating and each OR can be activated by multiple odorants of similar structure. The ORs are grouped into subfamilies based on the type of odorant structure detected. OR51V1 encodes the olfactory receptor family 51 subfamily V member 1. The nomenclature assigned to the OR genes and proteins for this organism is independent of other organisms. The β-globin gene locus is surrounded by a large cluster of OR genes. Polymorphisms in this gene associated with HbF levels in patients with sickle cell disease.
Synonyms: OR51A12
Comments:
N/A
Number of entries/variants: 6
Sequence Viewer
Publications / Origin
- Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R, Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters., Proc. Natl. Acad. Sci. U.S.A. , 97(26), 14560-5, 2000 PubMed
- Malnic B, Godfrey PA, Buck LB, The human olfactory receptor gene family., Proc. Natl. Acad. Sci. U.S.A. , 101(8), 2584-9, 2004 PubMed
- Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A, Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia., Proc. Natl. Acad. Sci. U.S.A. , 105(5), 1620-5, 2008 PubMed
- Van Ziffle J, Yang W, Chehab FF, Homozygous deletion of six olfactory receptor genes in a subset of individuals with Beta-thalassemia., PLoS ONE , 6(2), e17327, 2011 PubMed