GeneID: 136

Description:
PIK3CG is a crucial component of phosphoinositide 3-kinases (PI3Ks), a family of lipid kinases that act on cellular membranes to regulate a wide range of signalling cascades. They mediate phosphorylation of the 3'-OH group of phosphoinositides to produce a second messenger (PIP3), which in turn activates the serine/threonine kinase AKT and other downstream effector pathways. The encoded protein is a class I catalytic subunit that, together with a specific regulatory subunit, forms an active heterodimeric class I PI3K. PI3Ks play key roles in various cellular functions including cell growth, proliferation, differentiation, survival and motility. The PIK3CG gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. Polymorphisms in this gene associated with acute chest syndrome in sickle cell patients.

Synonyms: PI3K , PIK3 , PI3CG , PI3Kgamma , p110gamma , p120-PI3K

Comments:
N/A

Number of entries/variants: 2

1. Liu P, Cheng H, Roberts TM, Zhao JJ, Targeting the phosphoinositide 3-kinase pathway in cancer., Nat Rev Drug Discov , 8(8), 627-44, 2009 PubMed
2. Fertrin KY, Costa FF, Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment., Expert Rev Hematol , 3(4), 443-58, 2010 PubMed
3. Jean S, Kiger AA, Classes of phosphoinositide 3-kinases at a glance., J. Cell. Sci. , 127(0), 923-8, 2014 PubMed