GeneID: 143

Description:
The encoded protein belongs to the family of colony-stimulating factors (CSFs) that play pivotal roles in the survival, proliferation and differentiation of haematopoietic progenitors. The active form of the protein is found extracellularly as a homodimer. It exerts a broader effect on multiple cell lineages, especially macrophages and eosinophils, and acts directly on mature neutrophils to promote their antimicrobial activity. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Polymorphisms in this gene associated with stroke in sickle cell patients.

Synonyms: GM-CSF , GMCSF , colony stimulating factor 2 (granulocyte-macrophage)

Comments:
N/A

Number of entries/variants: 1

1. Gasson JC, Molecular physiology of granulocyte-macrophage colony-stimulating factor., Blood , 77(6), 1131-45, 1991 PubMed
2. Root RK, Dale DC, Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients., J. Infect. Dis. , 179(0), S342-52, 1999 PubMed
3. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005 PubMed