GeneID: 143
Names
| Common Name: | CSF2 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 5 (NC_000005.10) | Locus: | NG_033024.1 (CSF2) |
| HUGO Symbol: | CSF2 | Full Name: | colony stimulating factor 2 |
| Exons: | 4 | Introns: | 3 |
Description:
The encoded protein belongs to the family of colony-stimulating factors (CSFs) that play pivotal roles in the survival, proliferation and differentiation of haematopoietic progenitors. The active form of the protein is found extracellularly as a homodimer. It exerts a broader effect on multiple cell lineages, especially macrophages and eosinophils, and acts directly on mature neutrophils to promote their antimicrobial activity. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Polymorphisms in this gene associated with stroke in sickle cell patients.
Synonyms: GM-CSF , GMCSF , colony stimulating factor 2 (granulocyte-macrophage)
Comments:
N/A
Number of entries/variants: 1
Sequence Viewer
Publications / Origin
- Gasson JC, Molecular physiology of granulocyte-macrophage colony-stimulating factor., Blood , 77(6), 1131-45, 1991 PubMed
- Root RK, Dale DC, Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients., J. Infect. Dis. , 179(0), S342-52, 1999 PubMed
- Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005 PubMed