GeneID: 229


Common Name: FOXO3 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: N/A
HUGO Symbol: FOXO3 Full Name: forkhead box O3
Exons: 3 Introns: 2

The FOXO3 gene encodes a member of the class 'O' of forkhead-box (FOX) proteins (hence, FOXO). FOX proteins constitute a large family of transcription factors, which play a key role in the regulation of crucial biological processes, such as cellular proliferation, metabolism, inflammation, stress resistance, and apoptosis. FOX proteins are defined by a characteristic 'forkhead' box, a sequence of about 100 amino acids forming a motif that binds to DNA. This motif is also known as a 'winged-helix' DNA binding domain given its distinct butterfly-like appearance. FOXOs have four members and are tightly controlled by post-translational modifications. FOXO3 is expressed in nearly all tissues. FOXO3 protects cells against oxidative stress by increasing the production of ROS scavenging enymes, such as MnSOD and catalase. It has been shown to protect erythropoiesis against oxidative stress. Resveratrol, a natural phytoalexin with antioxidant properties used in β-thalassemia treatment, has been shown to activate FOXO3. FOXO3 is also critical for hematopoietic self-renewal. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Synonyms: FOXO2 , AF6q21 , FKHRL1 , FOXO3A , FKHRL1P2


Number of entries/variants: 0


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Publications / Origin

  1. Coffer PJ, Burgering BM, Forkhead-box transcription factors and their role in the immune system., Nat. Rev. Immunol. , 4(11), 889-99, 2004 PubMed
  2. Katoh M, Katoh M, Human FOX gene family (Review)., Int. J. Oncol. , 25(5), 1495-500, 2004 PubMed
  3. Marinkovic D, Zhang X, Yalcin S, Luciano JP, Brugnara C, Huber T, Ghaffari S, Foxo3 is required for the regulation of oxidative stress in erythropoiesis., J. Clin. Invest. , 117(8), 2133-44, 2007 PubMed
  4. Wang Y, Zhou Y, Graves DT, FOXO transcription factors: their clinical significance and regulation., Biomed Res Int , 2014(0), 925350, 2014 PubMed
  5. Lazarte SS, Mónaco ME, Terán MM, Haro AC, Achem MEL, Issé BA, Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects., Rev Bras Hematol Hemoter , 39(2), 115-121, 2017 PubMed
Created on 2017-07-04 14:11:56, Last reviewed on 2017-07-04 14:25:03 (Show full history)

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