GeneID: 241


Common Name: DRD2 Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_008841.1 (DRD2)
HUGO Symbol: DRD2 Full Name: dopamine receptor D2
Exons: 8 Introns: 7

This gene encodes the D2 subtype of the dopamine receptor, member of the family of G protein-coupled receptors. It is a 414-443 amino acid protein containing seven transmembrane domains. Alternative splicing of the sixth exon of the DRD2 gene results in the expression of short and long D2R isoforms, which are expressed throughout the brain. Outside of the central nervous system, D2R is expressed in the pituitary, retina, and kidney. D2R preferentially couples to and signals through the Gαo and Gαi proteins. Activation of these G-proteins leads to a decrease of cAMP production through inhibition of adenylyl cylase, and subsequent modulation of downstream signalling pathways. D2R is implicated in pain modulation. A polymorphism in the D2R gene has been associated with painful vaso-occlusive crisis episodes in sickle cell disease.

Synonyms: D2DR , D2R


Sequence Viewer

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Publications / Origin

  1. Montmayeur JP, Guiramand J, Borrelli E, Preferential coupling between dopamine D2 receptors and G-proteins., Mol. Endocrinol. , 7(2), 161-70, 1993 PubMed
  2. Albizu L, Holloway T, González-Maeso J, Sealfon SC, Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors., Neuropharmacology , 61(4), 770-7, 2011 PubMed
  3. Ortega-Legaspi JM, de Gortari P, Garduño-Gutiérrez R, Amaya MI, León-Olea M, Coffeen U, Pellicer F, Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain., Mol Pain , 7(0), 97, 2011 PubMed
  4. Wonkam A, Mnika K, Ngo Bitoungui VJ, Chetcha Chemegni B, Chimusa ER, Dandara C, Kengne AP, Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon., Br. J. Haematol. , 180(1), 134-146, 2018 PubMed
Created on 2018-01-31 17:54:37, Last reviewed on 2018-02-01 16:33:12 (Show full history)

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