GeneID: 282

Description:
Olfactory receptors (ORs) are members of a large family of G-protein-coupled receptors (GPCR) that transverse the membrane seven times and are located on the sensory neurons of nasal epithelium. The OR gene family is the largest in the genome and exists as clusters of genes in specific genomic locations. ORs bind to odorant molecules and transduce signals via a G protein, in turn activating downstream effector molecules that trigger the perception of smell. The olfactory system is highly discriminating and each OR can be activated by multiple odorants of similar structure. The ORs are grouped into subfamilies based on the type of odorant structure detected. OR51L1 encodes the olfactory receptor family 51 subfamily L member 1 and OR51P1P encodes the olfactory receptor family 51 subfamily P member 1 pseudogene. The nomenclature assigned to the OR genes and proteins for this organism is independent of other organisms. The β-globin gene locus is surrounded by a large cluster of OR genes. A variation in this intergenic region associated with haemolysis in cohorts of sickle cell disease patients.

Synonyms: N/A

Comments:
N/A

Number of entries/variants: 1

No available links

1. Malnic B, Godfrey PA, Buck LB, The human olfactory receptor gene family., Proc. Natl. Acad. Sci. U.S.A. , 101(8), 2584-9, 2004 PubMed
2. Niimura Y, Nei M, Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates., J. Hum. Genet. , 51(6), 505-17, 2006 PubMed
3. Milton JN, Rooks H, Drasar E, McCabe EL, Baldwin CT, Melista E, Gordeuk VR, Nouraie M, Kato GR, Kato GJ, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Rana S, Castro O, Zhang Y, Thein SL, Sebastiani P, Gladwin MT, , Steinberg MH, Genetic determinants of haemolysis in sickle cell anaemia., Br. J. Haematol. , 161(2), 270-8, 2013 PubMed