GeneID: 301

Description:
This gene encodes one of the several receptors for 5-hydroxytryptamine (serotonin). It is a 5-HT3 (5-hydroxytryptamine type 3) receptor, member of the Cys-loop family of transmitter-gated ion channels. The 5-HT3 receptor is a pentamer of subunits that assemble to form a central ion channel. It causes fast, depolarizing responses in neurons after activation. It is mainly functional as a heteropentameric complex with subunit A (HTR3A). Genetic variance in HTRB3 gene associated with acute chest syndrome (ACS) in patients with sickle cell disease. ACS is a form of acute lung injury caused by vaso-occlusion within the pulmonary microvasculature. Etiologies either trigger vaso-occlusion (e.g., infection, asthma, hypoventilation) or are a result of vaso-occlusion (e.g., bone marrow and fat emboli).

Synonyms: 5-HT3B

Comments:
N/A

Number of entries/variants: 1

1. Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA, A cytoplasmic region determines single-channel conductance in 5-HT3 receptors., Nature, 424(6946), 321-4, 2003 PubMed
2. Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
3. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed