GeneID: 309

Description:
The IL1R1 gene, formerly known as type I IL-1R, encodes a cytokine receptor that belongs to the interleukin-1 (IL-1) receptor (IL-1R) family. It binds to IL-1α and β, its receptor antagonist IL-1Ra and the truncated form of IL-38. Upon ligand binding, IL-1R1 further binds IL-1R accessory chains to form signaling receptor complexes. The biological effects of IL-1 are mainly inflammatory and include the induction of the production of inflammatory cytokines, toxic reactive oxygen and nitrogen species, prostaglandins, proteolytic enzymes and a variety of other factors. Genetic variance in IL1R1 gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: P80 , IL1R , IL1RA , CD121A , D2S1473 , IL-1R-alpha

Comments:
N/A

Number of entries/variants: 1

1. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
2. Boraschi D, Italiani P, Weil S, Martin MU, The family of the interleukin-1 receptors., Immunol. Rev., 281(1), 197-232, 2018 PubMed